I'm a software dev running my SmartNav 4 on a three-monitor setup, each monitor is on 1920 x 1080, and I've never had any problems.
The issue isn't so much the camera as your neck muscles. It takes a couple of weeks for the movement to become natural, but once you have a bit of practice and play with the speed and movement settings, it's easy to hit even small targets like the space between 2 characters or expand folders in windows explorer.
This is the place for comments, criticisms and even the occasional compliment related to the SmartNav drivers and profiler. Also the place to discuss and review support issues.